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In Vivo Imaging of Neutrophil Extracellular Traps (NETs): Visualization ...
WebApr 22, 2024 · Introduction. Neutrophil extracellular trap (NET) formation is a type of cell death distinct from apoptosis and necrosis [1, 2] that extends the classical neutrophil defense strategies of phagocytosis and degranulation [].NETs have been originally characterized as web-like extracellular structures composed of nuclear DNA, histones … WebAnti-DNA antibodies bind to DNA in NETs and are potent TLR9 stimulants, resulting in production of IFN-α by plasmacytoid DC (pDC). 34 Moreover, anti-RNP antibodies … hilger and watts ta4
DNA nets capture COVID-19 virus in low-cost rapid-testing platform
WebSep 23, 2024 · Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test – … WebMar 10, 2024 · "NETs form extracellularly―but cGAS is inside the phagocytes," said Falko Apel, first author of the study. "That's why we wanted to find out how cGAS and NETs come together." In their experiments, the scientists traced the path of NETs: phagocytes take up DNA remnants in their phagosome, a cell compartment that digests cell remains. WebJul 16, 2024 · Destruction of NETs DNA. Destruction of NETs structure at the primary or metastatic sites may represent another effective approach, which have the advantage of preserving antimicrobial functions of NETs in non-tumorous tissues. DNA, the backbone of the NETs structure, is therefore a feasible target for NETs degradation. smart 3 amplifier