WebOct 14, 2024 · We need to clarify that the terms polytherapy and polypharmacy are little bit different. Polytherapy means the use of multiple prescribed medications or their excessive administration, while polypharmacy means the use of multiple, also not prescribed, drugs not strictly necessary to an appropriate treatment [ 12 ]. WebMay 24, 2024 · Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China; Objective: The objectives of this study were to compare the risk and timing of seizure relapse in seizure-free patients with epilepsy following the withdrawal of monotherapy or polytherapy and to identify relevant influencing factors. Methods: Patients who had …

The use of chemicals for treatment of diseases is called:

WebNational Center for Biotechnology Information WebThe ED 50 is the most frequently used standardized dose by means of which the potencies of drugs are compared. Although one can determine the dose of drug predicted to be effective in one percent (ED 1) or 99 percent (ED 99) of a population, the ED 50 can be determined more precisely than other similar values. truflame gas springfield ga

Truly "rational" polytherapy: maximizing efficacy and minimizing …

WebPolytherapy has traditionally been considered to be associated with a higher risk of major congenital malformations than monotherapy. However, it has been shown the risks are primarily driven by the type of ASD included as polytherapy than the number of ASDs. 86 As a matter of fact, combination of sodium of valproate or topiramate is an independent risk … WebMar 1, 2024 · 1. Introduction. Management of epilepsy usually involves the long-term use of antiepileptic drugs (AEDs) and a substantial percentage of patients require polytherapy to control their seizures [1].The use of multiple AEDs poses a risk of drug interactions including enzyme induction or inhibition, alterations in protein-binding and expression of transporter … Webagainst polytherapy is the potential for chronic additive toxicity resulting from the use of multiple agents. The advantages of monotherapy over polytherapy are outlined in Table 1. In the late 1970s, two agents, effective as monotherapy, were emerging as the drugs of choice for most types of epilepsy: val proic acid and carbamazepine. tru flate air hose reel