Ribophagy receptor
WebbRecently, we revealed that folate-appended methyl-β-cyclodextrin (FA-M-β-CyD) provides selective antitumor activity in folate receptor-α (FR-α)-expressing cells by the induction of autophagy. In this study, to gain insight into the detailed mechanism of this antitumor activity, we focused on the induction of mitophagy by the treatment of FR-α … Webb17 okt. 2024 · Determination of the level of BNIP3L, a non-canonical mitophagy receptor, showed that its quantity did not change as compared with CR . Thus, a decrease in PINK1/Parkin can lead to a disturbance of mitophagy, and diminished levels of OPA1 prevent mitochondrial fusion processes for content exchange, leading to an impaired …
Ribophagy receptor
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Webbför 2 dagar sedan · However, with the discovery that autophagy and the expression of autophagy genes are induced under fed conditions by PPARA (peroxisome proliferator … Webb13 apr. 2024 · Stress-induced mitophagy, a tightly regulated process that targets dysfunctional mitochondria for autophagy-dependent degradation, mainly relies on two proteins, PINK1 and Parkin, which genes are mutated in some forms of familiar Parkinson’s Disease (PD). Upon mitochondrial damage, the protein kinase PINK1 …
Webb10 dec. 2024 · Thus, it is not known if AtNUFIP can act as a ribophagy receptor. Other plant organelles can be selectively targeted for degradation, most likely dependent on … WebbCD4 + T lymphocytes play a major role in the establishment and maintenance of immunity. They are activated by antigenic peptides derived from extracellular or newly synthesized (endogenous) proteins presented by the MHC-II molecules. The pathways leading to endogenous MHC-II presentation remain poorly characterized. We demonstrate here that …
Webb根据底物运送的方式区别，自噬一般可以分为大自噬（macroautophagy）、小自噬（microautophagy）和分子伴侣介导的自噬（chaperone-mediated autophagy, CMA） … Webb11 apr. 2024 · It has been poorly understood whether autophagy plays a protective or harmful role in β-cells, while we report here that it is dependent on NR3C1/glucocorticoid receptor activation. We proved that deleterious hyperactive autophagy happened only upon NR3C1 activation in β-cells under glucolipotoxic conditions, which eventually promoted …
WebbMacroautophagy (hereafter called autophagy) is a highly conserved physiological process that degrades over-abundant or damaged organelles, large protein aggregates and …
Webb28 feb. 2024 · In addition, it has been shown recently that mammalian NUFIP1 is a ribophagy receptor required for the selective autophagy of ribosomes during starvation … qr sims hairsWebb2.3. NUFIP1 is the Ribophagy Receptor in Mammalian Cells Selective autophagy receptors recognize specific cargoes and also bind to the autophagic protein Atg8 (LC3 in … qr sweetheart\u0027sWebb1) The mTOR complex 1 (mTORC1) is a central mediator in regulating the response to nutrients and growth signaling, and is a key regulator of autophagy.6The localization of … qr teacher\\u0027sWebbbinding to LC3B. The starvation-induced degradation of ribosomes via autophagy (ribophagy) depends on the capacity of NUFIP1 to bind LC3B and promotes cell survival. … qr studio fairmont wvWebbA selective ribophagy receptor for ribosome has been identified from human cell lines known as nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) ( Wyant et … qr shadowrocket viettelWebb31 maj 2024 · Thus a possible role of AtNUFIP1 as a receptor for ribophagy in plant is still questionable [[184, 185]]. Interestingly, in Arabidopsis autophagy deficient mutants such … qr sticker printer paperWebb12 apr. 2024 · AbstractRecent studies have shown that autophagy plays an important role in gynecologic tumors, and ubiquitin modification of autophagy regulatory components is essential to regulate autophagic flux. In this study, we found that the ubiquitin-conjugating enzyme E2C (UBE2C) affects endometrial cancer cell apoptosis and proliferation by … qr thermometer\\u0027s